CBD CLINICAL STUDIES & ARTICLES

CONDITION/ARTICLE       

ACNE                              

• The safety and efficacy of 3% Cannabis seeds extract cream for reduction of human cheek skin sebum and erythema content

• CBD as a Treatment for Acne?

• CBD exerts sebostatic and antiinflammatory effects on human sebocytes

• The endocannabinoid system of the skin in health and disease

• Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling

• Endocannabinoid signaling and epidermal differentiation

• Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions

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ADD/ADHD

• Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders

• CBD and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats

• Subtypes of ADHD and cannabis use

• Childhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students

• Oral delta 9-THC improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition

• Fitness to drive in spite (because) of THC

• ADHD Is Highly Prevalent in Patients Seeking Treatment for Cannabis Use Disorders

• A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD

• Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial

ADDICTION

• CBD as an Intervention for Addictive Behaviors 

• CBD reduces cigarette consumption in tobacco smokers

• Inhibition of monoacylglycerol lipase enzyme reduces nicotine withdrawal

• CBD inhibits the reward-facilitating effect of morphine 

• Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances 

• Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats 

• Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment

• Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010

• Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents

• Comparison of CBD, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity

• Transdermal delivery of CBD attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder

• CBD for the treatment of cannabis withdrawal syndrome

• Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents

• CBD Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway

• CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders

• Early Phase in the Development of CBD as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage

• Epigenetic mechanisms associated with addiction-related behavioural effects of nicotine and/or cocaine: implication of the endocannabinoid system

• Effects of Cannabidiol on Morphine Conditioned Place Preference in Mice

 ALZHEIMERS

• Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease

• The therapeutic potential of the endocannabinoid system for Alzheimer’s disease

• Endocannabinoid signalling in Alzheimer’s disease

• A molecular link between the active component of marijuana and Alzheimer’s disease pathology

• Neuroprotective effect of CBD… on beta-amyloid-induced toxicity in PC12 cells

• The Potential Therapeutic Effects of THC on Alzheimer’s Disease

• The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease 

• Cannabinoids for the treatment of dementia

• CBD in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression 

• CBD: A promising drug for neurodegenerative disorders?

• Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition

• The role of the endocannabinoid system in Alzheimer’s disease 

• The role of phytochemicals in the treatment and prevention of dementia 

• Cannabinoids for the treatment of dementia

• Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression inSHSY5YAPP+ Cells Through PPARγ Involvement

• Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic

• Can Marijuana Prevent Alzheimer’s?

• Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia

• Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease

• Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview

• Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model

• CBD Modulates the Expression of Alzheimer’s Disease-Related Genes in Mesenchymal Stem Cells

• In vivo Evidence for Therapeutic Properties of CBD for Alzheimer’s Disease

• Neurological aspects of medical use of CBD

ANTIBIOTIC RESISTANCE

• Antibacterial cannabinoids from Cannabis sativa: A structure-activity study (PubMed)

• Antibacterial activity of delta9-THC and CBD

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ANXIETY

• CBD as an anxiolytic drug

• Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa

• CBD reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients

• Neural basis of anxiolytic effects of CBD in generalized social anxiety disorder

• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation

• Effects of CBD on regional cerebral blood flow

• The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1Areceptors 

• The anxiolytic effect of CBD on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

• Plant-based medicines for anxiety disorders, part 2 

• A systematic review of plant-derived natural compounds for anxiety disorders

• The Endocannabinoid System and Anxiety

• CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders

• Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats

• Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.

• CBD Does Not Dampen Responses to Emotional Stimuli in Healthy Adults

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ARTHRITIS

• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis 

• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

• Involvement of the endocannabinoid system in osteoarthritis pain 

• The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55

• Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

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AUTISM

• Endocannabinoid Signaling in Autism

• Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain

• Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders

• A novel approach to the symptomatic treatment of autism

• Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders 

• Targeting the endocannabinoid system in the treatment of fragile X syndrome

• Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling

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BIPOLAR DISORDER

• Cannabinoids in bipolar affective disorder: A review and discussion of their therapeutic potential

• Cannabidiol was ineffective for manic episode of bipolar affective disorder

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BONE HEALTH

• CBD Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts

• Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies

• Cannabinoids and bone: Friend or foe?  

• Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells  

• Cannabinoids and the skeleton: From marijuana to reversal of bone loss  

• The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy 

• The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption  

• Endocannabinoids and the regulation of bone metabolism

• Cannabinoid receptors and the regulation of bone mass 

• Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health  

• Peripheral cannabinoid receptor, CB2, regulates bone mass  

• Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors 

• Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis  

• Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family

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CANCER

• CBD as potential anticancer drug

• The inhibitory effects of CBD on systemic malignant tumors

• CBD inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1

• CBD, a novel inverse agonist for GPR12

• Cannabinoids – a new weapon against cancer?

• CBD inhibits angiogenesis by multiple mechanisms

• Antitumorigenic targets of cannabinoids – current status and implications

• The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion

• In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma

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CHRONIC PAIN

• Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain

• Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain 

• Cannabis, pain, and sleep: Sativex Clinical Trials  

• Sativex successfully treats neuropathic pain characterised by allodynia: clinical trial  

• Cannabinoids for neuropathic pain

• Neuropathic orofacial pain: Cannabinoids as a therapeutic avenue

• Oromucosal delta9-THC/CBD for neuropathic pain associated with multiple sclerosis 

• The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain  

• Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation

• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy  

• Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain

• Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action

• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors  

• Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes

• Cannabinoids in the management of difficult to treat pain

• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain

• Marijuana extract helps prevent chemo pain

• Pot users less likely to take painkillers  

• CBD & THC interactions on acute pain and locomotor activity

• CBD Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats

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CROHN'S

• Cannabis finds its way into treatment of Crohn’s disease

• Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study

• Cannabinoids cool the intestine

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DIGESTIVE ISSUES

• CBD in inflammatory bowel diseases: a brief overview  

• Cannabis finds its way into treatment of Crohn’s disease 

• CBD reduces intestinal inflammation through the control of neuroimmune axis 

• Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis

• The effects of Delta-tetrahydrocannabinol and CBD alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

• Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice

• Cannabinoids and the gut: New developments and emerging concepts 

• Endocannabinoids and the gastrointestinal tract

• Cannabinoids and gastrointestinal motility: Animal and human studies  

• Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis

• Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review

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DEPRESSION

• Endocannabinoid system dysfunction in mood and related disorders

• Antidepressant-Like and Anxiolytic-Like Effects of CBD

• The endocannabinoid system and the treatment of mood and anxiety disorders  

• Endocannabinoid signaling in the etiology and treatment of major depressive illness

• Antidepressant-like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors

• Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants  

• Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa

• Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress 

• Serum contents of endocannabinoids are correlated with blood pressure in depressed women

• The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants

• Antidepressants and Changes in Concentration of Endocannabinoids and N-Acylethanolamines in Rat Brain Structures

• Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors

• Prohedonic Effect of CBD in a Rat Model of Depression

• Antidepressant-like and anxiolytic-like effects of CBD

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DIABETES

• The impact of marijuana use on glucose, insulin, and insulin resistance among US adults

• CBD attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy

• CBD lowers incidence of diabetes in non-obese diabetic mice

• Neuroprotective and blood-retinal barrier-preserving effects of CBD in experimental diabetes 

• Cannabidiol arrests onset of autoimmune diabetes in NOD mice

• Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation

• Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes

• The endocannabinoid system in obesity and type 2 diabetes

• Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes

• The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications

• Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain  

• Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats 

• Efficacy and Safety of CBD and THC-V on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes 

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ENDOCRINE DISORDERS

• Endocannabinoid system participates in neuroendocrine control of homeostasis

• The emerging role of the endocannabinoid system in endocrine regulation and energy balance  

• Endocannabinoids in endocrine and related tumours

• Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas

• The role of the endocannabinoid system in the neuroendocrine regulation of energy balance

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EPILEPSY AND SEIZURES

• Report of a parent survey of CBD-enriched cannabis use in pediatric treatment-resistant epilepsy 

• Medicinal marijuana stops seizures, brings hope to a little girl  

• Cannabinoids for epilepsy

• Cannabis, CBD, and epilepsy – From receptors to clinical response 

• The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability 

• Chronic administration of CBD to healthy volunteers and epileptic patients

• Endocannabinoid system protects against cryptogenic seizures 

• Seizing an opportunity for the endocannabinoid system

• Cannabidiol: promise and pitfalls

• Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders 

• Report of a parent survey of cannabidiol-enriched cannabis use in pediatrictreatment-resistant epilepsy

• From the Editors: Cannabidiol and medical marijuana for the treatment of epilepsy 

• Cannabidivarin (CBDV) suppressespentylenetetrazole (PTZ)-inducedincreases in epilepsy-related gene expression

• CBD exerts anti-convulsant effects in animal models of temporal lobe and partial seizures  

• Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo

• Hypnotic and antiepileptic effects of CBD

• The cannabinoids as potential antiepileptics 

• Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats  

• CBD Post-Treatment Alleviates Rat Epileptic-Related Behaviors

• Pharmacology of cannabinoids in the treatment of epilepsy

• Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection

• Report from a Survey of Parents Regarding the Use of Cannabidiol in Mexican Children with Refractory Epilepsy.

• Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy

• CBD Treatment for Refractory Seizures in Sturge-Weber Syndrome

• Could Cannabidiol be a Treatment Option for Intractable Childhood and Adolescent Epilepsy?

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FIBROMYALGIA

• Cannabis & fibromyalgia in Israel 

• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?  

• Cannabis use in patients with fibromyalgia 

• Cannabinoids for fibromyalgia

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GLAUCOMA

• Neuroprotective effect of (-)Delta9-THC and CBD in N-methyl-D-aspartate-induced retinal neurotoxicity 

• Effect of sublingual application of cannabinoids on intraocular pressure

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HEART DISEASE

• Study: History Of Cannabis Use Associated With Increased Survival Rates Among Heart Attack Patients

• CBD as an anti-arrhythmic, the role of the CB1 receptors  

• Is the cardiovascular system a therapeutic target for CBD?

• Acute administration of CBD in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion

• CBD attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy  

• The Effect of CBD on Ischemia/Reperfusion-Induced Ventricular Arrhythmias 

• CBD protects against myocardial ischemic reperfusion injury

• Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension

• Oleamide: A fatty acid amide signaling molecule in the cardiovascular system? 

• Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis

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HUNTINGTON'S DISEASE

• Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease 

• Cannabinoids: Novel medicines for the treatment of Huntington’s disease

• Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB(1) and CB(2) receptors

• Controlled clinical trial of cannabidiol in Huntington’s disease

• Prospects for cannabinoid therapies in basal ganglia disorders

• Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice

• Effects of a Sativex-Like Combination of Phytocannabinoids on Disease Progression in R6/2 Mice, an Experimental Model of Huntington’s Disease

• Neurological aspects of medical use of CBD

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INFLAMMATION

• Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

• The endocannabinoid system: an emerging key player in inflammation 

• Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

• Cannabinoids, endocannabinoids, and related analogs in inflammation

• Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor 

• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

• Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis

• Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation

• Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement  

• Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

• Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation

• Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death 

• Cannabinoids in clinical practice  

• Pure THC-V inhibits nitrite production in murine peritoneal macrophages

• Cannabinoids, inflammation, and fibrosis

• Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

• Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain

• Protective effect of CBD on hydrogen peroxide‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells

• Mechanisms of action of CBD in adoptively transferred experimental autoimmune encephalomyelitis

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IRRITABLE BOWEL SYNDROME

• Cannabidiol in inflammatory bowel diseases: A brief overview

• CBD reduces intestinal inflammation through the control of neuroimmune axis

• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

• Cannabinoid actions at TRPV channels: Effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation

• Therapeutic potential of cannabinoid-based drugs

• Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology)  

• CBD and the gut: New developments and emerging concepts

• Endocannabinoids and the gastrointestinal tract

• CBD and gastrointestinal motility 

• Getting into the weed: the role of the endocannabinoid system in the brain-gut axis

• Cannabinoids and GI Disorders: Endogenous and Exogenous

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MOOD DISORDERS

• Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders  

• The endocannabinoid system & the treatment of mood and anxiety disorders 

• The endocannabinoid system & psychiatric disorders

• The endocannabinoid system in the regulation of emotions throughout lifespan: A discussion on therapeutic perspectives  

• Endocannabinoid system dysfunction in mood and related disorders  

• Effects of CBD on regional cerebral blood flow  

• Cannabidiol, neuroprotection and neuropsychiatric disorders

• Therapeutic Potential of Cannabinoids in Psychosis

• Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?

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MULTIPLE SCLEROSIS

• Sativex for the management of multiple sclerosis symptoms

• THC & CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis  

• Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity  

• CBD provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors

• Oromucosal delta9-THC/CBD for neuropathic pain associated with multiple sclerosis 

• Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis

• Sativex long-term use: An open-label trial in patients with spasticity due to multiple sclerosis  

• A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis

• Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain

• Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain

• Evaluating Sativex in Neuropathic Pain Management

• CBD counteracted the development of experimental MS

• CBD/THC Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice

• Neurological aspects of medical use of CBD

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NAUSEA

• Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system

• CBD, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus  

• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation  

• Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews  

• Regulation of nausea and vomiting by cannabinoids 

• CBD: its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats  

• Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting 

• Effect of combined oral doses of THC & CBDA on acute and anticipatory nausea in rat models

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OCD

• Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour

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PARKINSON'S DISEASE

• Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial 

• Prospects for cannabinoid therapies in basal ganglia disorders

• Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: Importance of antioxidant and cannabinoid receptor-independent properties

• Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease

• Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movementsleep behaviour disorder in Parkinson’s disease patients 

• Cannabidiol for the treatment of psychosis in Parkinson’s disease  

• Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson’s disease

• Therapeutic potential of cannabinoids in CNS disease  

• CB2 Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson’s Disease

• Neurological aspects of medical use of CBD

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PTSD

• The endocannabinoid system provides an avenue for evidence-based treatment development forPTSD 

• Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks  

• Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear  

• Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors

• CBD blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of5HT1A receptors

• Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis 

• Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence

• Cannabinoid modulation of fear extinction brain circuits: A novel target to advance anxiety treatment

• The endocannabinoid system and extinction learning

• A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers 

• Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit

• Non-antidepressant long-term treatment in post-traumatic stress disorder

• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system

• The Use of Medicinal Marijuana for Posttraumatic Stress Disorder: A Review

• CBD Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System

• Bidirectional Effects of CBD on Contextual Fear Memory Extinction

• CBD disrupts the consolidation of specific and generalized fear memories via dorsal hippocampusCB1 and CB2 receptors

• Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

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RHEUMATISM

• Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress 

• Transdermal cannabidiol reduces inflammation and pain-related behaviors in a rat model of arthritis

• Cannabinoids as novel anti-inflammatory drugs

• Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

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SCHIZOPHRENIA

• Cannabis Drug Shows Promise in Treating Schizophrenia

• CBD as an antipsychotic drug  

• Cannabidiol as a potential treatment for psychosis 

• CBD enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

• Medical use of cannabis. CBD: A new light for schizophrenia?

• A critical review of the antipsychotic effects of CBD: 30 years of a translational investigation

• Peripheral endocannabinoid system dysregulation in first-episode psychosis 

• Cannabinoids and schizophrenia 

• Antipsychotic-like effects of cannabidiol and rimonabant

• CBD monotherapy for treatment-resistant schizophrenia

• Cannabis with high CBD content is associated with fewer psychotic experiences

• Marijuana compound treats schizophrenia with few side effects: Clinical trial 

• Clearing the smoke: what do we know about adolescent cannabis use and schizophrenia?

• Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments 

• Improved Social Interaction, Recognition and Working Memory with CBD Treatment in a Prenatal Infection Rat Model. 

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SKIN CONDITIONS

• Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis  

• CBD exerts sebostatic and antiinflammatory effects on human sebocytes 

• The endocannabinoid system of the skin in health and disease 

• Epigenetic control of skin differentiation genes by phytocannabinoids  

• A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ

• Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1

• Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation  

• Attenuation of allergic contact dermatitis through the endocannabinoid system

• Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus  

• The role of cannabinoids in dermatology  

• Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPKand p42/44 MAPK

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SLEEP DISORDERS

• The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent

• Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex 

• Effects of acute systemic administration of CBD on sleep-wake cycle in rats  

• Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults

• CBD modulates sleep in rats 

• Endocannabinoid modulation of cortical up-states and NREM sleep

• Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat  

• Endocannabinoid Signaling Regulates Sleep Stability

• Cannabis, Cannabinoids, and Sleep: a Review of the Literature

• Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.

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SPINAL CORD INJURY

• CBD-treated rats exhibited higher motor score after cryogenic spinal cord injury

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STRESS

• Endogenous cannabinoid signaling is essential for stress adaptation 

• Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders

• Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output

• Neuromodulators, stress and plasticity: a role for endocannabinoid signalling

• Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress  

• Endocannabinoids and stress

• Stress regulates endocannabinoid-CB1 receptor signaling

• Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus

• Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance

• Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression

• Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory

• The anxiolytic effect of CBD on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

• Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid

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STROKE

• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury  

• Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism  

• Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism

• Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function 

• Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice

• Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance  

• CBD reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke

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TRAUMATIC BRAIN INJURY

• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury  

• Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism  

• Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism

• Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function 

• Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice

• Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance  

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