THE ABCs OF CBD

Whether you are a current user or prospective user of CBD you may have many questions about this new entry into the healthcare marketplace.  Everyone is buzzing about CBD as it enters the wellness industry, but it is important that the CBD consumer is educated prior to trying this treatment.  As an informed consumer, you increase your chances of having a favorable experience and realizing a positive outcome.

Cannabidiol or CBD is a naturally occurring extract that can be found in both cannabis and hemp.  Cannabis and hemp come from the Cannabis sativa plant.  Hemp naturally has a lower content of THC, the compound that makes you high.  CBD that is marketed in the United States comes from hemp and must contain .3% THC or less to be legal.  CBD does not get you high, but even at .3% THC could show up on a standard drug test.  There are THC free CBD products available, and this is an important differentiating factor when choosing a CBD brand.  The sale of CBD is currently regulated at the state level and is legal in all states except Idaho, South Dakota and Nebraska.

 

HERE ARE SOME COMMON QUESTIONS ABOUT CBD

  

HOW CAN CBD BE EFFECTIVE FOR SO MANY DIFFERENT CONDITONS? 

Many people are confused as to how CBD can be successfully used to treat so many different conditions.  We are used to products that can be used in a very specific area with a limited therapeutic window, so how can CBD be touted as having efficacy in such varied conditions as an aid for inflammation, a pain reliever, an anxiety reducer and a protector of the nervous system?  The answer is that CBD works with your body’s endocannabinoid system (ECS).  The ECS was discovered in the 1990s and is a regulatory system that impacts so much of our bodies' regulatory mechanisms.  The body produces many positive natural chemicals that are broken down by naturally occurring enzymes.  CBD prevents these enzymes from inactivating your body’s naturally occurring chemicals.  Because CBD works with your regulatory system it is able to produce beneficial outcomes for many different conditions.

As a primer, the Mayo Clinic has released A Clinician's Guide to Cannabidiol and Hemp Oils. This article provides an overview of the scientific work on cannabinoids, CBD and hemp oils.

WHY ARE THERE SO FEW STUDIES ON CBD IN HUMANS?

Studying CBD in humans was under restrictions until the passage of the 2018 Farm Bill which opened up this area for research.  Although there are limited trials looking at the use of CBD in humans there is a large amount of pre-clinical research which has studied the efficacy of CBD in both the laboratory and in animal models.  The first FDA approved compound was Epidiolex which is approved for rare forms of epilepsy.  Most of the CBD hype has been driven by the many positive clinical outcomes that are experienced by current CBD users.  With time there will be the publication of human trials looking at CBD in the areas of pain, sleep issues, anxiety and depression.  In a December 2018 survey published in the journal Cannabis and Cannabinoid Research, about 62 percent of the survey’s 2,400 respondents said they take their CBD for a specific medical condition.  More than 35% claimed it works “very well” and only 4% said it didn’t work at all.

CLICK HERE FOR CURRENT CLINICAL TRIALS WITH CBD

 

WHAT DELIVERY SYSTEM WORKS BEST FOR MY CONDITION? 

CBD comes in many forms including ingestibles, sublinguals and topicals.  Ingestibles, such as gummy bears, are taken orally and can be quick and easy.  Before an ingestible works it must pass through the digestive system which can be a long process and may delay the activity of the CBD.  This route of administration may be a good choice for a chronic condition or daily use for general health.  Sublinguals, either drops or sprays, are taken and held under the tongue to allow absorption by the mucous membranes and allow the CBD to bypass the digestive system.  This process is faster than ingesting CBD.  Sublingual administration may be useful for both long term benefits or for conditions where you might need faster absorption.  The last of the most popular routes of administration are topicals such as creams and lotions.  It is effective for treating acute skin conditions or for treating muscles and pain-perceiving nerves.  Topicals are not for systemic absorption and should be used directly on the area of concern as topicals work locally.  

 

Some CBD products have enhanced delivery systems.  CBD is an oil, and everyone knows that oil and water don’t mix.  Enhanced delivery mechanisms such as liposomal delivery systems help with the absorption of CBD oils and can significantly increase the bioavailability of CBD.  Enhanced delivery systems can allow the consumer to achieve higher efficacy at a lower dose thereby reducing overall costs.

WHAT IS THE APPROPRIATE DOSE OF CBD?

When using CBD you should use a dose to effect approach.  

This means you start with the dosing printed on the label of your product and then increase the dose if you do not get your desired level of relief.  Below is a good guide on how to dose CBD to obtain the best level of efficacy:

 

  • Start with the recommended dose on the product's label.  Be on alert for adverse events or an allergic reaction.

  • Double the starting dose after one month should the desired affect not be achieved.  At this stage it will become apparent if CBD will be helpful or not.  Be prepared to stop CBD if you are not getting the desired results.

  • If you are seeing some benefit but still aren’t seeing enough change, consider spreading the dose throughout the day.

  • Continue to increase the dose until you have achieved your desired outcome.

  • Keep notes throughout the process and document how the different doses affect your body.  Always discuss your results with your doctor.

ARE THERE SIDE EFFECTS ASSOCIATED WITH CBD USE? 

When anything is ingested there is a chance for some type of adverse event and this is true with CBD as well.  First, make sure your CBD is grown on U.S. farms rather than overseas.  There is a higher chance of the CBD being tainted should it come from overseas suppliers.  Also, be cautious of CBD companies offering below market prices.  This could indicate they are skimping on quality control.  All the testing needed to ensure a quality CBD product is expensive and this testing will be reflected in the pricing of higher quality CBD products.  CBD is metabolized through the liver and those patients with liver conditions should use caution. Caution should also be used when using CBD in combination with other products metabolized by the liver.  The most commonly reported adverse events with CBD are dry mouth, low blood pressure, light headedness and drowsiness.

WHAT IS A CoA AND WHY IS IT IMPORTANT?

A reputable brand should offer a Certificate of Analysis (CoA) for it's product.  Make sure the manufacturer you are using just doesn’t do one test on the product. Make sure it tests its product at several stages during production.  The CoA should test the amount of CBD in the product and make sure that it is free of heavy metals and other contaminants.  Additionally, the CoA should be recent and it should be tied to a batch number that is tied to a lot number or QR code that can be found on the bottle.

 

WHY DO PEOPLE SAY 'BUYER BEWARE' WHEN BUYING CBD?  

In 2017 there was a study published in the Journal of the American Medical Association that looked at the labeling  accuracy of cannabidiol extracts sold online.  Eighty- four products were purchased from 31 different companies.  Each of these products were tested for CBD and THC content.  The study found that only 31% of the products were accurately labeled.  Additionally, THC was detected in 43% of products.  When purchasing a CBD product be sure the CBD has a CoA linked to the batch you are using and make sure it shows the appropriate level of CBD and that the product is 100% THC free.  The THC content in this study was at a level that could cause intoxication or impairment.  As mentioned before, even though a level of .3% THC or less is legal, that level may still produce a positive drug test.  The best way to know if your product is THC free is by investigating the level of THC via the CoA.

CBD BUYERS CHECKLIST

  • Third-Party Lab Tested

  • Advanced Delivery System

  • 100% THC Free

  • USA Grown Hemp

  • FDA cGMP Certified

             

The founders of Verity Therapeutics have over 50 years’ experience working for major multi-national branded pharmaceutical companies.  They hold Verity CBD products to the same standards of purity, quality and safety that you would expect from a major pharmaceutical  company.  

 

All of Verity’s premium CBD products undergo rigorous testing throughout the manufacturing process by top third-party labs to verify quality and purity and ensure there are no additives or chemicals.  Verity includes a QR code on all packaging with test results and Certificates of Analysis (CoA).  You can be confident in the quality of all ingredients and product concentrations.  Verity’s manufacturing facilities are certified by the FDA as adhering to Current Good Manufacturing Practices (cGMP Certified).  Verity’s unique liposomal delivery system has taken the natural benefits of hemp and given them an added boost increasing absorption and bioavailability. All Verity products are 100% THC free – you can be sure by pulling up your Verity product’s CoA. 

 

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